abstract：:One of the major obstacles in dissecting the mechanism of pathology in human primary biliary cirrhosis (PBC) has been the absence of animal models. Our laboratory has focused on a model in which mice, following immunization with a xenobiotic chemical mimic of the immunodominant autoepitope of the E2 component of pyruv...

journal_title：Clinical and experimental immunology

authors： Shimoda S,Tsuneyama K,Kikuchi K,Harada K,Nakanuma Y,Nakamura M,Ishibashi H,Hisamoto S,Niiro H,Leung PS,Ansari AA,Gershwin ME,Akashi K

更新日期：2012-06-01 00:00:00

abstract：:Interleukin (IL)-22 is a cytokine involved in inflammatory and wound healing processes that is secreted primarily by T helper type 17 (Th17) cells. IL-22 receptor (IL-22R) expression is limited to epithelial cells of the digestive organs, respiratory tract and skin. Most tumours originating in these sites over-express...

journal_title：Clinical and experimental immunology

authors： Curd LM,Favors SE,Gregg RK

更新日期：2012-05-01 00:00:00

abstract：:The hypothesis that a virus might in some way be involved in the causation of type 1 diabetes has a long history, but decades of research have failed to resolve the issue beyond reasonable doubt. Viruses could potentially play a primary role in the pathogenesis of type 1 diabetes by initiating autoimmunity, a secondar...

journal_title：Clinical and experimental immunology

authors： Gale EA

更新日期：2012-04-01 00:00:00

abstract：:Excessive T helper type 1 (Th1) cell activity has been reported in Behçet's disease (BD). Recently, association of Th17 cells with certain autoimmune diseases was reported, and we thus investigated circulating Th17 cells in BD. CD4(+) CD45RO(-) (naive) T cells were cultured with Th0-, Th1-, Th2- and Th17-related cyto...

journal_title：Clinical and experimental immunology

authors： Shimizu J,Takai K,Fujiwara N,Arimitsu N,Ueda Y,Wakisaka S,Yoshikawa H,Kaneko F,Suzuki T,Suzuki N

更新日期：2012-04-01 00:00:00

abstract：:Tolerance to lipopolysaccharide (LPS) constitutes a stress adaptation, in which a primary contact with LPS results in a minimal response when a second exposure with the same stimulus occurs. However, active important defence mechanisms are mounted during the tolerant state. Our aim was to assess the contribution of po...

journal_title：Clinical and experimental immunology

authors： Landoni VI,Chiarella P,Martire-Greco D,Schierloh P,van-Rooijen N,Rearte B,Palermo MS,Isturiz MA,Fernández GC

更新日期：2012-04-01 00:00:00

abstract：UNLABELLED:OTHER THEMES PUBLISHED IN THIS IMMUNOLOGY IN THE CLINIC REVIEW SERIES Allergy, Host Responses, Cancer, Type 1 diabetes and viruses, Metabolic diseases. SUMMARY:Initiation of a successful immune response requires a working set of sensors that detect any noxious agent within the cellular microenvironment and ...

journal_title：Clinical and experimental immunology

authors： Mankan AK,Kubarenko A,Hornung V

更新日期：2012-03-01 00:00:00

abstract：:Patients with functional deficiency of C1-inhibitor (C1-INH) suffer from recurrent acute attacks (AA) of localized oedema associated with activation of the contact system, complement and fibrinolysis. To unravel further the role of coagulation and fibrinolysis in the pathophysiology of C1-INH deficiency, we performed ...

journal_title：Clinical and experimental immunology

authors： van Geffen M,Cugno M,Lap P,Loof A,Cicardi M,van Heerde W

更新日期：2012-03-01 00:00:00

abstract：:In recent years galectin-3 has gained attention as a signalling molecule, mainly in inflammatory diseases. Data on galectin-3 expression in neonates, however, are limited, and expression of this lectin in cord blood has not yet been reported. The aim of this study was to determine galectin-3 levels in cord blood of te...

journal_title：Clinical and experimental immunology

authors： Demmert M,Faust K,Bohlmann MK,Tröger B,Göpel W,Herting E,Härtel C

更新日期：2012-02-01 00:00:00

abstract：:Renal allograft survival is related directly to cell senescence. In the transplantation scenario many cellular events - participating as immunological and non-immunological factors - could contribute to accelerate this biological process, responsible for the ultimate fate of the graft. Mechanisms concerned in toleranc...

journal_title：Clinical and experimental immunology

authors： Furuzawa-Carballeda J,Lima G,Alberú J,Palafox D,Uribe-Uribe N,Morales-Buenrostro LE,Reyes Acevedo R,Mondragón G,Chevaile A,Llorente L

更新日期：2012-02-01 00:00:00

abstract：:Haematopoietic stem cell transplantation (HSCT) is an immunological treatment that has been used for more than 40 years to cure a variety of diseases. The procedure is associated with serious side effects, due to the severe impairment of the immune system induced by the treatment. After a conditioning regimen with hig...

journal_title：Clinical and experimental immunology

authors： Bemark M,Holmqvist J,Abrahamsson J,Mellgren K

更新日期：2012-01-01 00:00:00

abstract：:Members of the European Society for Immunodeficiencies (ESID) and other colleagues have updated the multi-stage expert-opinion-based diagnostic protocol for non-immunologists incorporating newly defined primary immunodeficiency diseases (PIDs). The protocol presented here aims to increase the awareness of PIDs among d...

journal_title：Clinical and experimental immunology

authors： de Vries E,European Society for Immunodeficiencies (ESID) members.

更新日期：2012-01-01 00:00:00

abstract：:Because activation of the alternative pathway (AP) of the complement system is an important aspect of both age-related macular degeneration (AMD) and rheumatoid arthritis (RA), we wished to address the question whether genetic risk factors of the AP inhibitor complement factor H (CFH) for AMD would also be risk factor...

journal_title：Clinical and experimental immunology

authors： Trouw LA,Böhringer S,Daha NA,Stahl EA,Raychaudhuri S,Kurreeman FA,Stoeken-Rijsbergen G,Houwing-Duistermaat JJ,Huizinga TW,Toes RE

更新日期：2011-12-01 00:00:00

abstract：:Eosinophils contribute to the pathogenesis of bullous pemphigoid (BP) by secretion of proinflammatory cytokines and proteases. Trafficking of eosinophils into tissue in animal models and asthma depends on interleukin-5 and a family of chemokines named eotaxins, comprising CCL11, CCL24 and CCL26. Up-regulation of CCL11...

journal_title：Clinical and experimental immunology

authors： Günther C,Wozel G,Meurer M,Pfeiffer C

更新日期：2011-11-01 00:00:00

abstract：:Myeloid FcαRI, a receptor for immunoglobulin (Ig)A, mediates cell activation or inhibition depending on the type of ligand interaction, which can be either multivalent or monovalent. Anti-inflammatory signalling is triggered by monomeric targeting using anti-FcαRI Fab or IgA ligand binding, which inhibits immune and n...

journal_title：Clinical and experimental immunology

authors： Watanabe T,Kanamaru Y,Liu C,Suzuki Y,Tada N,Okumura K,Horikoshi S,Tomino Y

更新日期：2011-11-01 00:00:00

abstract：:Little is known about the ability of hepatitis C virus (HCV) to alter early innate immune responses in infected patients. Previous studies have shown that natural killer (NK) cells are functionally impaired after interaction of recombinant HCV glycoprotein E2 with the co-stimulatory CD81 molecule in vitro; however, th...

journal_title：Clinical and experimental immunology

authors： Farag MM,Weigand K,Encke J,Momburg F

更新日期：2011-09-01 00:00:00

abstract：:Dysfunction of T cells is a common feature in chronic persistent viral infections, including hepatitis C virus (HCV), and although hepatic and peripheral T cells have been studied extensively in chronic HCV hepatitis, the role of splenic T cell responses in such patients is poorly defined. This is an important issue, ...

journal_title：Clinical and experimental immunology

authors： Hashimoto N,Shimoda S,Kawanaka H,Tsuneyama K,Uehara H,Akahoshi T,Kinjo N,Taketomi A,Shirabe K,Akashi K,Lleo A,Ansari AA,Gershwin ME,Maehara Y

更新日期：2011-08-01 00:00:00

abstract：:The objective of this study was to evaluate prospectively the relationship between Yersinia enterocolitica (YE) infection and the development of overt autoimmune hypo- or hyperthyroidism (study A) and the de novo occurrence of thyroid antibodies (study B). This was a prospective cohort study of 790 euthyroid women who...

journal_title：Clinical and experimental immunology

authors： Effraimidis G,Tijssen JG,Strieder TG,Wiersinga WM

更新日期：2011-07-01 00:00:00

abstract：:Oestradiol and the selective oestrogen receptor modulator (SERM) raloxifene have been shown to ameliorate collagen-induced arthritis (CIA) in rats and in mice. One aim was to investigate if raloxifene exerts its anti-arthritic and anti-osteoporotic effects during the induction or effector phase of arthritis. A second ...

journal_title：Clinical and experimental immunology

authors： Jochems C,Islander U,Erlandsson M,Engdahl C,Lagerquist M,Ohlsson C,Nandakumar KS,Holmdahl R,Carlsten H

更新日期：2011-07-01 00:00:00

abstract：:The capacity of microbial products to inhibit allergic inflammation make them logical candidates for novel therapies in allergic diseases such as atopic dermatitis. To assess the effects of intradermal Mycobacterium vaccae derivative on allergen-specific immune responses in children with moderate to severe atopic derm...

journal_title：Clinical and experimental immunology

authors： Dunstan JA,Brothers S,Bauer J,Hodder M,Jaksic MM,Asher MI,Prescott SL

更新日期：2011-06-01 00:00:00

abstract：:Disseminated infection with virulent Mycobacterium avium in C57Bl/6 (B6) mice leads to severe lymphocyte depletion in secondary lymphoid organs. In this study, we found an up-regulation of caspase-8 activity in spleen cell extracts from M. avium 25291-infected B6 mice compared to non-infected mice. The activation of t...

journal_title：Clinical and experimental immunology

authors： Borges M,Rosa GT,Appelberg R

更新日期：2011-06-01 00:00:00

abstract：:A growing body of evidence points to autophagy as an essential component in the immune response to tuberculosis. Autophagy is a direct mechanism of killing intracellular Mycobacterium tuberculosis and also acts as a modulator of proinflammatory cytokine secretion. In addition, autophagy plays a key role in antigen pro...

journal_title：Clinical and experimental immunology

authors： Ní Cheallaigh C,Keane J,Lavelle EC,Hope JC,Harris J

更新日期：2011-06-01 00:00:00

abstract：:Enormous progress has been made during the last 25 years in our understanding of the aetiopathogenesis of the anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides (AAV). This has led to improvements in early diagnosis, treatment and secondary prevention of these diseases. Nevertheless, there are sti...

journal_title：Clinical and experimental immunology

authors： Kallenberg CG

更新日期：2011-05-01 00:00:00

abstract：:The era prior to 1990 was a time of careful observation of disease presentation, course, outcomes and meticulous pathology studies. These mainly single-centre studies introduced new life-saving therapies for drugs still used effectively today. In the 1970-1980s, cyclophosphamide (CyP) added to glucocorticosteroids (GC...

journal_title：Clinical and experimental immunology

authors： Hoffman GS

更新日期：2011-05-01 00:00:00

abstract：:Circulating immunoglobulin (Ig)G antibodies against M(2) muscarinic acetylcholine receptors (M(2) mAChR) have been implicated in Chagas' disease (ChD) pathophysiology. These antibodies bind to and activate their target receptor, displaying agonist-like activity through an unclear mechanism. This study tested the abili...

journal_title：Clinical and experimental immunology

authors： Beltrame SP,Auger SR,Bilder CR,Waldner CI,Goin JC

更新日期：2011-05-01 00:00:00

abstract：:Human immunodeficiency virus (HIV)-1 protease is a known target of CD8+ T cell responses, but it is the only HIV-1 protein in which no fully characterized HIV-1 protease CD4 epitopes have been identified to date. We investigated the recognition of HIV-1 protease by CD4+ T cells from 75 HIV-1-infected, protease inhibit...

journal_title：Clinical and experimental immunology

authors： Muller NG,Alencar R,Jamal L,Hammer J,Sidney J,Sette A,Brindeiro RM,Kalil J,Cunha-Neto E,Moraes SL

更新日期：2011-04-01 00:00:00

abstract：:Tuberculosis is a worldwide health problem, and multidrug-resistant (MDR) and extensively multidrug-resistant (XMDR) strains are rapidly emerging and threatening the control of this disease. These problems motivate the search for new treatment strategies. One potential strategy is immunotherapy using cationic anti-mic...

journal_title：Clinical and experimental immunology

authors： Rivas-Santiago CE,Rivas-Santiago B,León DA,Castañeda-Delgado J,Hernández Pando R

更新日期：2011-04-01 00:00:00

abstract：:Insulin autoantibodies (IAA) can appear in children within months of introducing solid foods to the diet and before clinical type 1 diabetes. The aim of this study was to determine whether infant dietary antigens could be immunizing agents of IAA. To this end, IAA binding to [(125) I]insulin was competed with food pre...

journal_title：Clinical and experimental immunology

authors： Adler K,Mueller DB,Achenbach P,Krause S,Heninger AK,Ziegler AG,Bonifacio E

更新日期：2011-04-01 00:00:00

abstract：:The immune modulating capacity of vitamin D(3) is well-recognized. Ultra-violet (UV) exposure determines production of vitamin D(3) in vivo and varies through the course of the year, especially in temperate regions. However, it is not known whether the human innate immune response differs due to seasonality. To valida...

journal_title：Clinical and experimental immunology

authors： Khoo AL,Chai LY,Koenen HJ,Sweep FC,Joosten I,Netea MG,van der Ven AJ

更新日期：2011-04-01 00:00:00

abstract：:Pleural tuberculosis (TB) remains a common presentation of Mycobacterium tuberculosis (MTB) infection in HIV/TB dually infected subjects, and both cellular and acellular components of the pleural milieu promote HIV-1 replication; however, they remain uncharacterized. Using cytokine array of pleural fluid and real-time...

journal_title：Clinical and experimental immunology

authors： Toossi Z,Hirsch CS,Wu M,Mayanja-Kizza H,Baseke J,Thiel B

更新日期：2011-03-01 00:00:00

abstract：:Transmembrane activator and calcium modulator and cyclophilin ligand interactor-immunoglobulin (TACI-Ig) is a human fusion protein that binds and neutralizes both B lymphocyte stimulator (BLyS), a cytokine shown to be a key regulator of B cell maturation, proliferation and survival, and a proliferation-inducing ligand...

journal_title：Clinical and experimental immunology

authors： Wang D,Chang Y,Wu Y,Zhang L,Yan S,Xie G,Qin Q,Jin J,Wang W,Fang J,Wei W

更新日期：2011-02-01 00:00:00

abstract：:Autoimmune T cell responses directed against insulin-producing β cells are central to the pathogenesis of type 1 diabetes (T1D). Detection of such responses is therefore critical to provide novel biomarkers for T1D 'immune staging' and to understand the mechanisms underlying the disease. While different T cell assays ...

journal_title：Clinical and experimental immunology

authors： Mallone R,Mannering SI,Brooks-Worrell BM,Durinovic-Belló I,Cilio CM,Wong FS,Schloot NC,T-Cell Workshop Committee, Immunology of Diabetes Society.

更新日期：2011-01-01 00:00:00

abstract：:Previous studies have shown that neutralization of macrophage migration inhibitory factor (MIF) by anti-MIF antibody reduces intestinal inflammation in mice. In this study we tested whether or not anti-MIF autoantibody induced by DNA vaccine targeting MIF protects mice against experimental colitis. Mice were administe...

journal_title：Clinical and experimental immunology

authors： Ohkawara T,Koyama Y,Onodera S,Takeda H,Kato M,Asaka M,Nishihira J

更新日期：2011-01-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory disease that develops as a result of the interaction between genetic and environmental risk factors. Although increasing evidence shows the importance of genes in determining the risk of RA, it is clear that environmental factors also have a vital role. Studies to da...

journal_title：Clinical and experimental immunology

authors： Colebatch AN,Edwards CJ

更新日期：2011-01-01 00:00:00

abstract：:This study tested the hypothesis that pregnant female baboons exhibit increased levels of various inflammatory mediators in serum resulting from ligature-induced periodontitis, and that these profiles would relate to periodontal disease severity/extent in the animals. The animals were sampled at baseline (B), mid-preg...

journal_title：Clinical and experimental immunology

authors： Ebersole JL,Steffen MJ,Holt SC,Kesavalu L,Chu L,Cappelli D

更新日期：2010-12-01 00:00:00

abstract：:Lidocaine, bupivacaine or ropivacaine are used routinely to manage perioperative pain. Sparse data exist evaluating the effects of local anaesthetics (LA) on fibroblasts, which are involved actively in wound healing. Therefore, we investigated the effects of the three LA to assess the survival, viability and prolifera...

journal_title：Clinical and experimental immunology

authors： Fedder C,Beck-Schimmer B,Aguirre J,Hasler M,Roth-Z'graggen B,Urner M,Kalberer S,Schlicker A,Votta-Velis G,Bonvini JM,Graetz K,Borgeat A

更新日期：2010-11-01 00:00:00

abstract：:Type 1 diabetes (T1D) is an autoimmune disease caused by the T cell-mediated destruction of the pancreatic insulin-producing beta cells. Currently there are no widely accepted and standardized assays available to analyse the function of autoreactive T cells involved in T1D. The development of such an assay would great...

journal_title：Clinical and experimental immunology

authors： Mannering SI,Wong FS,Durinovic-Belló I,Brooks-Worrell B,Tree TI,Cilio CM,Schloot NC,Mallone R,Immunology of Diabetes Society T-Cell Workshop Committee.

更新日期：2010-11-01 00:00:00

abstract：:We have shown that immunization with dendritic cells (DCs) pulsed with hepatitis B virus core antigen virus-like particles (HBc-VLP) packaging with cytosine-guanine dinucleotide (CpG) (HBc-VLP/CpG) alone were able to delay melanoma growth but not able to eradicate the established tumour in mice. We tested whether, by ...

journal_title：Clinical and experimental immunology

authors： Song S,Zhang K,You H,Wang J,Wang Z,Yan C,Liu F

更新日期：2010-10-01 00:00:00

abstract：:The success of pregnancy depends upon regulatory mechanisms that allow the fetus to survive and develop to term in the uterus, despite maternal immune cells' awareness of paternal alloantigens. At least some of these specific mechanisms are mediated by the effect of fetal trophoblast cells. In the present study we exa...

journal_title：Clinical and experimental immunology

authors： Talayev VY,Matveichev AV,Lomunova MA,Talayeva MV,Tsaturov ME,Zaichenko IY,Babaykina ON

更新日期：2010-10-01 00:00:00

abstract：:Anti-endothelial cell antibodies (AECA) have been frequently detected in systemic vasculitis, which affects blood vessels of various sizes. To understand the pathogenic roles of AECA in systemic vasculitis, we attempted to identify target antigens for AECA comprehensively by a proteomic approach. Proteins extracted fr...

journal_title：Clinical and experimental immunology

authors： Karasawa R,Kurokawa MS,Yudoh K,Masuko K,Ozaki S,Kato T

更新日期：2010-09-01 00:00:00

abstract：:Stress known to stimulate sympathetic activity, as well as the hypothalamic-pituitary-adrenal axis (HPA), produces a significant increase in adrenomedullin (AdM) levels, suggesting a regulatory or protective role for AdM in countering HPA activation that follows a variety of stressors. Stressors can modulate the secre...

journal_title：Clinical and experimental immunology

authors： Yildirim NC,Yurekli M

更新日期：2010-07-01 00:00:00